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jak2 inhibitor azd1480  (Cayman Chemical)

 
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    Cayman Chemical jak2 inhibitor azd1480
    Jak2 Inhibitor Azd1480, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/jak2 inhibitor azd1480/product/Cayman Chemical
    Average 90 stars, based on 1 article reviews
    jak2 inhibitor azd1480 - by Bioz Stars, 2026-02
    90/100 stars

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    resource source identifier jak2 inhibitor azd1480 medchemexpress cat  (MedChemExpress)
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    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
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    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
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    Fig. 3 Effect of OSM on <t>JAK2/STAT3</t> signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001
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    Fig. 9 <t>JAK2-STAT3</t> signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 <t>(AZD1480)</t> or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group
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    Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 3 Effect of OSM on JAK2/STAT3 signalling pathway during early and middle osteogenic differentiation of tendon stem cells. (A) After OSM-induced osteogenic differentiation of tendon stem cells for 7 days, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test. (B)Fourteen days after OSM-induced osteogenic differentiation of tendon stem cells, expression of OSMR, GP130, p-JAK2, and p-STAT3 proteins was detected by western blotting (n = 3). Two-tailed Student’s t-test.Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Expressing, Western Blot, Two Tailed Test, Standard Deviation

    Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 4 OSM promotes early and mid-stage osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. (A, B,E)After 7 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alkaline phosphatase staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins as well as osteogenic marker genes was analysed by western blotting and qPCR(n = 3). One-way ANOVA. (C, D,F) After 14 days of OSM-induced osteogenic differentiation in the presence of AZD1480 and stattic, alizarin red staining was performed. Scale bar represents 200 μm. Expression of p-JAK2 and p-STAT3 proteins and osteogenic marker genes were analysed by western blotting and qPCR, respectively (n = 3). One-way ANOVA. Data are presented as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Staining, Expressing, Marker, Western Blot, Standard Deviation

    Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively

    Journal: Journal of orthopaedic surgery and research

    Article Title: Oncostatin M promotes osteogenic differentiation of tendon-derived stem cells through the JAK2/STAT3 signalling pathway.

    doi: 10.1186/s13018-024-04915-5

    Figure Lengend Snippet: Fig. 5 OSM promotes osteogenic differentiation of tendon stem cells through the JAK2/STAT3 signalling pathway. OSM binds to the tendon stem cell receptor OSMR/GP130, activating and phosphorylating JAK2. Phosphorylated JAK2 activates STAT3 downstream, and phosphorylated STAT3 forms a dimer that translocates to the nucleus and binds to DNA to regulate gene transcription. AZD1480 and stattic inhibit activation and phosphorylation of JAK2 and STAT3, respectively

    Article Snippet: To further analyse the effect of JAK2/STAT3 signalling on osteogenic differentiation of TDSCs, JAK2 inhibitor AZD1480 (10 μM, Santa Cruz Biotechnology, Dallas, TX), STAT3 inhibitor stattic (5 μM, Santa Cruz Biotechnology), or DMSO was added to the osteogenic differentiation medium with 25 ng/mL recombinant OSM to differentiate TDSCs for 7 and 14 days.

    Techniques: Activation Assay, Phospho-proteomics

    Fig. 9 JAK2-STAT3 signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 (AZD1480) or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group

    Journal: Nutrition & metabolism

    Article Title: Spexin ameliorated obesity-related metabolic disorders through promoting white adipose browning mediated by JAK2-STAT3 pathway.

    doi: 10.1186/s12986-024-00790-3

    Figure Lengend Snippet: Fig. 9 JAK2-STAT3 signaling pathway inhibitors eliminate the adipose browning induced by SPX. The adipocytes were treated with an inhibitor of JAK2 (AZD1480) or an inhibitor of STAT3 (stattic). (A ~ D) The protein expression of UCP1, TBX1 and CIDEA treated with AZD1480 and stattic. (E) The expression levels of mitochondrial biogenesis proteins CYT-B. (F) The mRNA expression of UCP1, TBX1 and CIDEA. All values are represented as means with error bars representing S.D. In the bar graph, *, P < 0.05; **, P < 0.01. n = 6 for each group

    Article Snippet: Antibodies UCP1 (ab10983), TBX1 (ab109313) and CIDEA (ab8402) were purchased from Abcam (Cambridge, UK), Actin (AP0063), JAK2 (3230), STAT3 (12,640), p-JAK2 (3771) and p-STAT3 (9145) were from Cell Signaling Technology (Boston, MA, USA), and JAK2-specific inhibitor AZD1480 (S2162), STAT3-specific inhibitor stattic (S7024) was from Selleck.cn (Shanghai, China).

    Techniques: Expressing